A deep Chandra observation of the interacting star-forming galaxy Arp 299

We present results from a 90 ks Chandra ACIS-S observation of the X-ray luminous interacting galaxy system Arp 299 (NGC 3690/IC 694). We detect 25 discrete X-ray sources with luminosities above 4.0x10^38 erg s^-1 covering the entire Ultra Luminous X-ray source (ULX) regime. Based on the hard X-ray spectra of the non-nuclear discrete sources identified in Arp 299, and their association with young, actively star-forming region of Arp 299 we identify them as HMXBs. We find in total 20 off-nuclear sources with luminosities above the ULX limit, 14 of which are point-like sources. Furthermore we observe a marginally significant deficit in the number of ULXs, with respect to the number expected from scaling relations of X-ray binaries with the star formation rate (SFR). Although the high metalicity of the galaxy could result in lower ULX numbers, the good agreement between the observed total X-ray luminosity of ULXs, and that expected from the relevant scaling relation indicates that this deficit could be the result of confusion effects. The integrated spectrum of the galaxy shows the presence of a hot gaseous component with kT = 0.72+-0.03 keV, contributing 20% of the soft (0.1-2.0 keV) unabsorbed luminosity of the galaxy. A plume of soft X-ray emission in the west of the galaxy indicates a large scale outflow. We find that the AGN in NGC 3690 contributes only 22% of the observed broad-band X-ray luminosity of Arp 299.Comment: 20 pages, 14 figures, 9 tables. Accepted for publication in MNRA

Abundance and temperature of the outer hot circum-Galactic medium: The SRG/eROSITA view of the soft X-ray background in the eFEDS field

Despite their vital importance to understand galaxy evolution and our own Galactic ecosystem, our knowledge of the physical properties of the hot phase of the Milky Way is still inadequate. However, sensitive SRG/eROSITA large area surveys are now providing us with the long sought-after data needed to mend this state of affairs. We present the properties of the soft X-ray emission as observed by eROSITA in the eFEDS field. We measure the temperature and metal abundance of the hot circum-Galactic medium (CGM) to be within $kT_{CGM}=0.153-0.178$ keV and $Z_{CGM}=0.052-0.072$ $Z_\odot$, depending on the contribution of solar wind charge exchange (SWCX). Slightly larger CGM abundances $Z_{CGM}=0.05-0.10$ $Z_\odot$ are possible, considering the uncertain extrapolation of the extragalactic Cosmic X-ray background (CXB) emission below $\sim1$ keV. To recover CGM abundances as large as $Z_{CGM}=0.3$ $Z_\odot$, it must be postulated the presence of an additional component, likely associated with the warm-hot intergalactic medium, providing $\sim15-20$% of the flux in the soft X-ray band. The emission in the soft band is dominated by the CGM, with contributions from the CXB and the local hot bubble. Moreover, the eROSITA data require the presence of an additional component associated with the elusive Galactic corona plus a possible contribution from unresolved M dwarf stars. This component has a temperature of $kT\sim0.4-0.7$ keV and it might be out of thermal equilibrium. It contributes $\sim9$% to the total emission in the 0.6--2 keV band, therefore it is a likely candidate to produce part of the unresolved CXB flux observed in X-ray ultra-deep fields. We also observe a significant contribution to the soft X-ray flux due to SWCX, during periods characterised by stronger solar wind activity, and causing the largest uncertainty on the determination of the CGM temperature.Comment: Accepted for publication in Astronomy and Astrophysic

Study of the excess Fe XXV line emission in the central degrees of the Galactic centre using XMM-Newton data

The diffuse Fe XXV (6.7 keV) line emission observed in the Galactic ridge is widely accepted to be produced by a superposition of a large number of unresolved X-ray point sources. In the very central degrees of our Galaxy, however, the existence of an extremely hot (~7 keV) diffuse plasma is still under debate. In this work we measure the Fe XXV line emission using all available XMM-Newton observations of the Galactic centre (GC) and inner disc (-10 < l < 10, -2 < b < 2). We use recent stellar mass distribution models to estimate the amount of X-ray emission originating from unresolved point sources, and find that within a region of l = ±1 and b = ±0.25 the 6.7keV emission is 1.3-1.5 times in excess of what is expected from unresolved point sources. The excess emission is enhanced towards regions where known supernova remnants are located, suggesting that at least a part of this emission is due to genuine diffuse very hot plasma. If the entire excess is due to very hot plasma, an energy injection rate of at least ~6 × 1040 erg s-1 is required, which cannot be provided by the measured supernova explosion rate or past Sgr A∗ activity alone. However, we find that almost the entire excess we observe can be explained by assuming GC stellar populations with iron abundances ~1.9 times higher than those in the bar/bulge, a value that can be reproduced by fitting diffuse X-ray spectra from the corresponding regions. Even in this case, a leftover X-ray excess is concentrated within l = ±0.3 and b = ±0.15, corresponding to a thermal energy of ~2 × 1052 erg, which can be reproduced by the estimated supernova explosion rate in the GC. Finally we discuss a possible connection to the observed GC Fermi-LAT excess

Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia : phenotypes, risk factors and genotypes

Publisher Copyright: © 2022 Ferrata Storti Foundation Published under a CC BY-NC license.Central nervous system (CNS) toxicity is common at diagnosis and during treatment of pediatric acute lymphoblastic leukemia (ALL). We studied CNS toxicity in 1, 464 children aged 1.0-17.9 years, diagnosed with ALL and treated according to the Nordic Society of Pediatric Hematology and Oncology ALL2008 protocol. Genome-wide association studies, and a candidate single-nucleotide polymorphism (SNP; n=19) study were performed in 1, 166 patients. Findings were validated in an independent Australian cohort of children with ALL (n=797) in whom two phenotypes were evaluated: diverse CNS toxicities (n=103) and methotrexate-related CNS toxicity (n=48). In total, 135/1, 464 (9.2%) patients experienced CNS toxicity for a cumulative incidence of 8.7% (95% confidence interval: 7.31-10.20) at 12 months from diagnosis. Patients aged ≥10 years had a higher risk of CNS toxicity than had younger patients (16.3% vs. 7.4%; P<0.001). The most common CNS toxicities were posterior reversible encephalopathy syndrome (n=52, 43 with seizures), sinus venous thrombosis (n=28, 9 with seizures), and isolated seizures (n=16). The most significant SNP identified by the genome-wide association studies did not reach genomic significance (lowest P-value: 1.11x10-6), but several were annotated in genes regulating neuronal functions. In candidate SNP analysis, ATXN1 rs68082256, related to epilepsy, was associated with seizures in patients <10 years (P=0.01). ATXN1 rs68082256 was validated in the Australian cohort with diverse CNS toxicities (P=0.04). The role of ATXN1 as well as the novel SNP in neurotoxicity in pediatric ALL should be further explored.Peer reviewe

Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study

\ua9 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley &amp; Sons Ltd.Steroids are a mainstay in the treatment of acute lymphoblastic leukaemia (ALL) in children and adolescents; however, their use can cause clinically significant steroid-related neuropsychiatric symptoms (SRNS). As current knowledge on SRNS during ALL treatment is limited, we mapped the phenotypes, occurrence and treatment strategies using a database created by the international Ponte di Legno Neurotoxicity Working Group including data on toxicity in the central nervous system (CNS) in patients treated with frontline ALL protocols between 2000 and 2017. Ninety-four of 1813 patients in the CNS toxicity database (5.2%) experienced clinically significant SRNS with two peaks: one during induction and one during intensification phase. Dexamethasone was implicated in 86% of SRNS episodes. The most common symptoms were psychosis (52%), agitation (44%) and aggression (31%). Pharmacological treatment, mainly antipsychotics and benzodiazepines, was given to 87% of patients while 38% were hospitalised due to their symptoms. Recurrence of symptoms was reported in 29% of patients and two previously healthy patients required ongoing pharmacological treatment at the last follow up. Awareness of SRNS during ALL treatment and recommendation on treatment strategies merit further studies and consensus